Asian Journal of Research in Chemistry
  • Year: 2011
  • Volume: 4
  • Issue: 3

RP-HPLC Method for the Estimation of Atorvastatin Calcium in Bulk and Pharmaceutical Formulations

  • Author:
  • P. Nagaraju1,, B. Sridhar2, P. Jitendra Kumar3, U. Upendra Rao1, K. Hanumantha Rao2, P.N.V. Gopal1
  • Total Page Count: 3
  • Page Number: 434 to 436

1Hindu College of Pharmacy, Amaravathi Road, Guntur – 522 002, Andhra Pradesh

2DCRM Pharmacy College, Inkollu, Andhra Pradesh

3Siddhartha Institute of Pharmacy, Sattenapalli, Andhra Pradesh

*Corresponding Author E-mail: raju_pharma35@rediffmail.com

Online published on 6 March, 2013.

Abstract

The present work describes a simple reverse phase HPLC method for the estimation of Atorvastatin calcium in bulk and pharmaceutical formulations. The estimation was carried out on phenomenex C18 (250 × 4.6 mm, 5μ) column using a mobile phase containing of Acetonitrile: Ortho-phosphoric acid (0.1%): Tetrahydrofuran (48:0.04:52). The eluent was monitored at 244 nm. The results have been validated statistically and recovery studies confirmed the accuracy of proposed method.

Keywords

HPLC, Validation, Atorvastatin calcium, Pharmaceutical formulation