Synthesis of new 7-(3-(benzo[d]thiazol-2-ylamino) propoxy)-4-methyl-2Hchromen-2-one derivatives with Atypical Antipsychotic activity

A new series of 7-(3-(benzo[d]thiazol-2-ylamino)propoxy)-4-methyl-2H-chromen-2-one derivatives(4a-4k) were synthesized and evaluated for their D₂ and 5HT₂ antagonistic activity as a measure of atypical antipsychotic property. Most of these compounds showed dopamine D₂ receptor antagonistic activity from moderate to high potency along with serotonin 5-HT₂ receptor blockage activity. The dopamine D₂ and serotonin 5-HT₂ receptor blockage activity was evaluated by inhibition of apomorphine-induced climbing behavior and 5HTP induced head twitches in mice respectively. Compounds 7-(3-(benzo[d]thiazol-2-ylamino)propoxy)-4-methyl-2H-chromen-2-one derivatives (4a-4k) were synthesized by addition of various 2-amino benzothiazoles substituted derivatives (3a-3k) with 7-(3-Chloropropoxy)-4-methyl-2H-chromen-2-one(2) refluxing in dry pyridine. The synthesized compounds were characterized with the help of spectral and analytical study.