Simultaneous Estimation of Cefixime Trihydrate and Ofloxacin by UV Spectrophotometer Using Multicomponent Method

A new simple, specific, precise and accurate multicomponent method has been developed for simultaneous estimation of Cefixime (CEF) and Ofloxacin (OFL) in capsule formulation. The detection of the constituents was done using UV detector at 262,269,278,281,286 for CEF and OFL. Recovery, study values of CEF and OFL is 100.04±0.34 and 99.98±0.27 respectively, relative standard deviation of less than 2% for the assay and linearity coefficient of 0.9998 that the method is precise, accurate and linear in the concentration given and demonstrated the method developed is rugged. Liner response obtained for CEF was in the concentration range 5–20 μg/mL and OFL in the range 2–10 μg/mL.