Adaptation of Color Reactions for Spectrophotometric Determination of Mosapride Citrate in Formulations

Three new, simple and sensitive visible spectrophotometric methods (A, B and C) have been developed for the determination of Mosapride Citrate in bulk drug and pharmaceutical formulations. Method A is based on the condensation of Mosapride Citrate with salicylaldehyde to form schiff's base, which was a yellow colored chromogen exhibiting λ_max at 410 nm. Method B is based on the formation of pink colored chromogen obtained when Mosapride Citrate was diazotized with nitrous acid followed by coupling with α-naphthyl amine, exhibiting λ_max at 520 nm. Method C is based on the oxidation of Mosapride Citrate with Fe (III) and the estimation of Fe (II) produced after chelation with potassium ferricyanide, which was a bluish green colored chromogen, exhibiting λ_max at 770 nm. The Beer's law was obeyed in the concentration range of 4–20, 10–40 and 4–24 μg/ml for methods A, B and C respectively. The results of the proposed methods have been validated statistically and by recovery methods.