Simultaneous Estimation of Atorvastatin Calcium and Clopidogrel Bisulphate Using Multicomponent Method

A new simple, specific, precise and accurate Multicomponent method has been developed for simultaneous estimation of Atorvastatin Calcium (ATOR) and Clopidogrel Bisulphate (CLOP) in tablet formulation. The detection of the constituents was done using UV detector at 219,225,232,237,246 for ATOR and CLOP. Recovery, study values of ATOR and CLOP is 100.04±0.34 and 98.99±0.27 respectively, relative standard deviation of less than 2% for the assay and linearity coefficient of 0.9998 that the method is precise, accurate and linear in the concentration given and demonstrated the method developed is rugged. Liner response obtained for ATOR was in the concentration range 20100μg/mL and CLOP in the range 20–100 μg/mL.