An accurate and precise RP-HPLC method was developed for the determination of lornoxicam in bulk and tablet dosage forms. Separation of the drug was achieved on a reverse phase C18 column using a mobile phase consisting of phosphate buffer and methanol in the ratio of 65:35 v/v. The pH was adjusted to 3.0 with orthophosphoric acid. The flow rate was 1.5 ml/min and the detection wavelength was 289 nm. The linearity was observed in the range of 30–150 μg/ml with a correlation coefficient of 0.999. The proposed method was validated for its linearity, accuracy, precision and robustness. This method can be employed for routine quality control analysis of lornoxicam in tablet dosage forms.
Lornoxicam, Estimation, RP-HPLC, Validation
