A simple, accurate, precise, reproducible and economical procedure for simultaneous estimation of Fenofibrate (FENO) and Metformin hydrochloride (MET) in tablet dosage form as well as in bulk drugs have been developed using double beam UV Spectrophotometer. The method based on solving of simultaneous equation using 239 nm (λmax of FENO) and 218 nm (λmax of MET) as two analytical wavelengths for both drugs. The method was found to be linear in the range of 1 – 6 μgml−1 and 3.125–18.75 μgml−1 with mean recovery of 99.6% and 101.82% of fenofibrate and metformine hydrochloride, respectively. The solution of both drugs was prepared using Methanol as a solvent. The proposed method is suitable for simultaneous determination of Fenofibrate and Metformin hydrochloride in pharmaceutical dosage form.
Fenofibrate, Metformine hydrochloride, Methanol, U.V, Simultaneous equation method
