1Sri Vasavi Institute of Pharmaceutical Sciences, Tadepalligudem-534 101, Andhra Pradesh, India
2V.V. Institute of Pharmaceutical Sciences, Gudlavalleru-521 356, Andhra Pradesh, India
*Corresponding Author E-mail: dralrao@gmail.com
Online published on 6 March, 2013.
An accurate and precise HPLC method was developed for the determination of trandolapril. Separation of the drug was achieved on a reverse phase C18 column using a mobile phase consisting of phosphate buffer and acetonitrile in the ratio of 35:65 v/v. The flow rate was 0.8 ml/min and the detection wavelength was 210 nm. The linearity was observed in the range of 20–60 μg/ml with a correlation coefficient of 0.999. The proposed method was validated for its linearity, accuracy, precision and robustness. This method can be employed for routine quality control analysis of trandolapril in tablet dosage forms.
Trandolapril, Estimation, RP-HPLC, Validation, Tablets
