Asian Journal of Research in Chemistry
  • Year: 2011
  • Volume: 4
  • Issue: 9

Synthesis and Evaluation of antioxidant and anti-inflammatory activity of Conjugates of Amino Acids with N-Aroyl-N, N′-Dicyclohexyl Urea

  • Author:
  • Shakti Prasanna Sahoo1,, Bharat Bhusan Subudhi2, Rachana Swain1
  • Total Page Count: 4
  • Page Number: 1485 to 1488

1A.K.R.G. College of Pharmacy, Nallajerla, West Godavari, Andhra Pradesh,-534112. India

2School of Pharmaceutical Sciences, Siksha O Anusandhan University, Bhubaneswar, Orissa, -751003. India

*Corresponding Author E-mail: sahoo.shakti@gmail.com

Online published on 6 March, 2013.

Abstract

A series of 2-((2-3-benzoyl-1,3-dicyclohexylureido)-2-oxoethyl)amino)-3-(4hydroxyphenyl) propanoic acid (3a) and its analogs were synthesized from N,N′-Dicyclohexylcarbodiimide (DCC) by acetylating and finally condensing with amino acids to yield good antioxidant molecules which are showing the potency nearer to ascorbic acid and exploring their anti inflammatory activity.

Keywords

Amino acid, N-aroyl-N, N′-dicyclohexyl urea, Antioxidant, DPPH