Asian Journal of Research In Chemistry

  • Year: 2012
  • Volume: 5
  • Issue: 10

Spectrophotometric Determination of Ritonavir

  • Author:
  • Ch. V.R. Murthy1,, M.L.N. Acharyulu2, T.S. Reddy3
  • Total Page Count: 3
  • DOI:
  • Page Number: 1268 to 1270

1Department of Chemical Engg, A.U.C.E(A), A.U College of Engineering, Visakhapatnam, A.P

2VITAM College of Engineering, Mindivani Palem, Ananadapuram Mandal, Visakhapatnam-531173

3DLR College (Degree and P.G Courses), Gollalamamidada, E.G. Dist., A.P, 533344

Abstract

A new simple spectrophotometric method for the assay of Ritonavir (RIT) has been described. Haematoxylin, [7,11-bdihydrobenzb-indeno-(1,2-d)-pyran-3,4,6a,9,10-6(h)-pentol] is a catechol derivative from the log wood (haematoxylin campeachianum), when treated with an oxidizing agent, undergoes oxidation to yield haematin. The coloured species formation may be attributed to the formation of charge transfer complex between in situ formed haematin from haematoxylin-Chloramine-T and hetero sulphur with lone pair of electrons present in thiazole moiety acts as electron donor in Ritonavir (RIT). The λmax was at 550nm.The proposed method is selective, simple and accurate. The results obtained are reproducible and statistically validated.

Keywords

Spectrophotometric, Ritonavir, Haematoxylin, Chloramine-T, Charge transfer-complex