Synthesis, Characterization and Antimicrobial activity of Some Schiff Bases of 2-Amino-4-(4-Acetamido Phenyl)thiophene-3-carboxamide

2-Amino-4-(4-acetamido phenyl) Thiophene-3carboxamide was synthesized using versatile Gewald reaction.First step is preparation of cyanoacetamide which was carried out by condensation of ammonia (25%) and ethyl cyano acetate which was then reacted with p-acetanilido acetophenone, sulphur, diethyl amine to give 2-Amino-4-(4-acetamido phenyl) thiophene-3carboxamide.Later the compound was treated with twelve different substituted aryl aldehydes to yield twelve new Schiff bases(SM 1a-1l). The compounds were characterized IR, 1H NMR and mass spectral data and screened for antimicrobial activity.