Synthesis, Characterisation and CNS Activity of 1,3-bis(2-hydroxybenzylidene)thiourea and 2-(2-hydroxybenzylidene amino) Acetic acid Schiff bases

The Schiff bases 1,3-bis(2-hydroxybenzylidene)thiourea and 2-(2-hydroxybenzylidene amino) acetic acid were prepared from salicylaldehyde, thiourea and glycine by condensation method using standard procedure. CNS activity of these schiff bases were studied using albino rats of both the sexes. Animals were divided into four groups, each consisting of four animals. Group 1 served as standard caffeine, group 2 received standard chlorpromazine drug. Group 3 received 250 mg/kg of 1,3-bis(2-hydroxybenzylidene)thiourea and group 4 received as 2-(2hydroxybenzylidene amino) acetic acid. CNS depressant activity of these compounds were measured by placing the rat individually in the actophotometer for 10 min. Among 1,3-bis (2-hydroxy benzylidene) thiourea(41.17%) and 2-(2hydroxyl benzylidene amino)acetic acid Schiff bases, 2-(2-hydroxyl benzylidene amino)acetic acid(69.71%) possessed highest depressant activity than that of chlorpromazine(60.54%) with a probability <0.5.