Method Development and Validation of Rilpivirine in bulk and Pharmaceutical Tablet Dosage Form by using UV – Visible Spectrophometric Method.

The present research work discusses the development of UV Spectrophotometric method for the determination of Rilpivirine in bulk and pharmaceutical tablet dosage form. The present method is simple, rapid, accurate, precise and economical when compared to other methods. The absorption maxima of the drug were found to be 282nm for Rilpivirine in methanol solvent system. The method is applied to tablet dosage form it gives best results of accuracy, precision & linearity over a range of 2–8μg/ml for Rilpivirine. The percentage recovery was found to be 101% for Rilpivirine. Results were analysed and validated for various parameters as per ICH guidelines.