1Department of Organic Chemistry, Foods, Drugs and Water, School of Chemistry, Andhra University, Visakhapatnam –530 003, India
2DLR College (Degree and P.G Courses), Gollalamamidada, E.G. Dtt, A.P, 533344
3VITAM College of Engg, Mindivani Palem, Ananadapuram Mandal, Visakhapatnam, 531173
*Corresponding Author E-mail: tsreddy68@yahoo.com; vasudevamln12@rediffmail.com
Online published on 7 February, 2013.
Two simple and sensitive visible spectrophotometric methods (M1,M2) are developed for estimation of Rizatriptan (RZT) in bulk and dosage forms. They are based on the formation of colored species with Sodium Nitro prusside-Acetaldehyde (SNP-ACD, Method M1) and Cobalt thiocyanate (CTC, Method M2) reagents exhibiting maximum absorption at 560 nm and 635 nm respectively. Methods M1, M2 obeyed Beer's law limits in the range of 0.52.5□g/ml(M1) and 0.5–2.5□g/ml(M2) respectively and are statistically validated. The proposed methods are selective, simple and economical for the quantitative determination of Rizatriptan.
spectrophotometriy, Rizatriptan(RZT), Cobaltthiocyanate(CTC), SodiumNitroprusside-acetaldehyde (SNP-ACD)
