Department of Biochemistry, University of Madras, Guindy Campus, Chennai – 600 025, Tamilnadu, India
*Corresponding Author E-mail: subbus2020@yahoo.co.in
Online published on 7 February, 2013.
Dyslipidemia is one of the main causative factors for the progression of vascular complications in diabetes. Recently, we have reported the hypoglycemic and antioxidant properties of Annona squamosa leaves extract on streptozotocin induced diabetic rats. In the present study, streptozotocin induced diabetic rats were treated with Annona squamosa leaves extract (100 mg/kg b.w./day) for 30 days and at the end of the treatment period the status of the lipid profile in the serum, liver and kidney was evaluated. The increased levels of lipid contents in serum and tissues observed in diabetic rats were reverted back to near normal levels by the administration of the extract. Also the decreased levels of HDL cholesterol and increased levels of LDL cholesterol in serum of diabetic rats were restored to near normal levels by the treatment with the leaves extract. The results of the present study clearly indicate that the Annona squamosa leaves extract possess potent hypolipidemic activity in addition to its hypoglycemic and antioxidant potential. The phytoconstituents present in the extract might account for the observed pharmacological action.
Annona squamosa, streptozotocin, antihyperlipidemic nature
