Synthon Approach in Designing Organic Synthesis: A Case Study of Rational Synthesis Design of a Potent Antidiabetic Agent “Rosiglitazone.”

Synthon approach advocated by Prof. E. J. Corey of Harvard University has emerged as a powerful analytical tool of design synthetic routes for the preparation of an organic compound of any interest from readily available starting materials. This approach plays a vital role in the synthesis of medicinal compounds/drugs which is a part and parcel of modern drug discovery process. Taking the privilege of this approach, a good number of synthesis schemes has been proposed for a potent anti-diabetic agent “rosiglitazone” keeping an overview on the works published in both journals and patent literatures. The proposed synthesis planning being a theoretical investigation, the actual laboratory execution requires the cross examination of a considerable number of factors such as reactions, reagents and order of events. In actual practice, generally that route is most feasible which is cost-effective, safe, and easy to carry out and produces maximum yield in a short reaction time.