In vitro pharmacological activity of the whole plant Naregamia alata.

Naregamia alata (Meliaceae) has been used in traditional medicines in India and elsewhere in the treatment of rheumatism, itch, malarial and chronic fevers, wounds, anaemia, enlarged spleen, ulcers, vitiated conditions of pitta and vata, halitosis, cough, asthma, splenomegaly, scabies, pruritis, dysentery, dyspepsia and catarrh. The in vitro antioxidant assay of the methanol extract was done by DPPH radical scavenging assay and showed moderate activity. Reducing power assay and Super oxide radical scavenging also showed moderate activity. IC₅₀ Values of DPPH Radical Scavenging and Super oxide radical scavenging are compared. Antibacterial activity of the Pet.Ether, Chloroform and Methanol extracts against Gram positive and Gram negative bacteria were done using disc diffusion method. The chloroform extract showed remarkable activity against the tested organisms, while the others showed only moderate activity. Antifungal activity also done and Pet.ether extract having highest activity than the others.