Spectrophotometric Methods for the Estimation of Cinitapride and Omeprazole in Bulk and Oral Dosage Form

Different UV spectrophotometric methods have been developed for the estimation of Cinitapride (CNP) and omeprazole (OME) in both bulk and capsule dosage form. Both the drugs were well soluble in methanol. CNP and OME showed absorption maximum at 262nm and 301nm respectively using methanol as solvent. Both the drugs obeyed Beer's law showing linearity in the range of 4–20μg/ml with correlation coefficient of 1. Method A is the standard absorbance method, method B involves determination of the Area under curve (AUC) and method C and D are the First and Second derivative of the Zero order spectrum respectively. The developed procedures were analyzed for specificity, limit of detection (LOD), limit of quantification (LOQ), linearity of response, precision and accuracy. Thus the proposed method could be adopted for routine analysis of the formulation.