Synthesis and Antifungal Screening of Novel 1-methyl-2-aminophenyl-4(N⁴-alkyl/aryl piperazinyl) benzimidazole Derivatives

Benzimidazole and piperazine derivatives play an important role in biological field such as antibacterial, antiviral and antifungal activity. The increasing drug resistant pathogens lent additional urgency for development of new antifungal agents. In present work N¹-methyl-2-chloro benzimidazole was condensed with 1-alkyl/aryl -4-(4’-aminophenyl) piperazines to 1-methyl-2-aminophenyl-4-(N⁴-alkyl/arylpiperazinyl) benzimidazole derivatives. The structural elucidation of synthesized compounds is done by IR, 1H-NMR, Mass spectral analysis. Benzimidazole and piperazine derivatives synthesized are screened for their antifungal potential. The turbidimetric method is used antifungal activity against Trichophyton rubrum ATCC9029 and Candida albicans ATCC10231. The compounds showed moderate activity as compared to ketoconazole.