Synthesis and evaluation of antibacterial activity of some Benzopyran-4-one derivatives

In view of the general observations that Benzopyrone derivatives are associated with antibacterial, anti-inflammatory, anticancer, antihepatotoxic activity etc. it was our interest to prepare different substituted Benzopyrone derivatives and evaluate them for their antibacterial activity.A series of substituted benzopyran-4-one derivatives were synthesized through various steps starting from 2-benzoyloxy-4-substituted acetophenone. The structures of the synthesized compounds were confirmed by their spectral and analytical data. Out of all synthesized compounds 6a and 6b and compounds 6f, 6i and 6k showed maximum activity against E.coli and S.aureus.