Study of Quality Control and Uncertainty in Multiresidue Pesticide Estimation in Packaged Drinking Water Using GC-MS/MS

A method was developed and validated for the simultaneous determination of 15 Organochlor pesticides residues in packaged drinking water by gas chromatography coupled to a triple quadrupole mass analyzer (GC/-MS/MS), mainly using the selected reaction monitoring (SRM) mode. The recovery data were obtained by spiking blank samples of packaged drinking water at concentration levels of 0.09 μg/L, yielding recoveries in the range 70–110%. Precision values expressed as relative standard deviation (RSD) were in the range of 4.7 -18.4%. Linearity was studied in the range 10–200ng/L and the coefficient of correlation was higher than 0.98% for all compounds. Method Detection Limits (MDLs) and limits of quantification (LOQs) were established. The overall uncertainty of the method was estimated. According to the validation data and performance characteristics as well as the high sample throughput, the proposed method is suitable for routine application.