Design, Synthesis and Characterization of Some Novel Amino and Aldehyde Substituted Azaphenothiazines

Some novel series of amino and aldehyde substituted azaphenothiazines were synthesized by condensation of 2-chloro-1-(10H-azaphenothiazin-10yl)ethanone with various amines and aryl aldehydes. As it is known that substituted aldehyde and amine when attached with some alkyl chain or heterocyclic moiety can lead to potentially biological active compound. The structure modification for their better biological activity includes substitution on nitrogen at 10th position coupled with aliphatic/aromatic amine and aromatic aldehydes. The above result established the fact that azaphenothiazine can be a rich source of biologically active compounds. The synthesized compounds were confirmed with IR, 1HNMR and Mass spectroscopy. The bioavailability of compounds was determined by Lipinski rule of 5 using customized software.