Asian Journal of Research In Chemistry

  • Year: 2012
  • Volume: 5
  • Issue: 7

Syntheses of Biologically active 1-[2-(1,3-Dimethyl-2,6-Dioxo-1,2,3,6Tetrahydro-Purin-7-Yl)-Acetyl]-3-(Substituted Phenyl)-1H-Pyrazole-4- Carbaldehyde

  • Author:
  • Freddy H. Havaldar, Azadkumar S. Sharma
  • Total Page Count: 4
  • DOI:
  • Page Number: 827 to 830

Nadkarny-Sacasa Research Laboratory Department of Chemistry, St. Xavier's College, Mumbai -400 001, Maharashtra, India

Abstract

1-[2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-yl)-acetyl]-3-(substituted phenyl)-1H-pyrazole-4-carbaldehydes (4a-e) have been synthesized by the cyclisation of (1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-purin-7yl)-acetic acid [1-(substituted phenyl)-ethylidene]-hydrazides (3a-e) with phosphorous oxychloride in N,Ndimethylformamide. The pyrazoles have been characterized on the basis of analytical and spectral data and screened for biological activity.

Keywords

Synthesis, Pyrazoles, Antibacterial, antifungal activity