Synthesis and Antimicrobial Activity of Some Indole Derivatives

Present work deals with the preparation of Ethyl 1H-indole-5-caboxylate by refluxing indole-5-carboxylic acid and ethyl iodide in the presence of DMF (dimethyl formamide). Further, Ethyl 1H-indole-5-carboxylate treated with hydrazine hydrate gives 1H-indole-5-carbohydrazide which is treated with various substituted aromatic aldehydes to form indole derivatives.Hydrazides were synthesized so as to increase intracellular concentration and so as to try and decrease the resistance developed due to decrease intracellular concentration of the drug. The synthesized aldehyde derivatives were characterized on the basis of physical, analytical and spectral (IR, ¹HNMR and Mass) data. Further, these were tested for anti-bacterial activity against S. aureus (ATCC 29213), E.coli (ATCC 25922), Pseudomonas aeruginosa (MTCC 741)andanti-fungal activity against Aspergilusniger, Candida albicans(ATCC 9025)in cup plate method. Evaluation of the compound revealed moderate to good antimicrobial activity.