Synthesis and evaluation of antimicrobial activity of some 5-[(5-substituted furan-2-yl) methylene]-(3H)-3-substituted benzyl-4-thioxo thiazolidine-2one derivatives

A series of thiazolidine-2, 4-dione was prepared as potential antimicrobial agents by conventional method. All the synthesised compounds have been screened for their antibacterial activity against S. aureus, E.coli and antifungal activity against C.albicans. The identification and characterization of the synthesised compounds were carried out by melting point, thin layer chromatography, ¹H NMR, IR, and MASS spectra. Among the synthesised compounds, compound (IIIb and IIIf) showed better antimicrobial activity as compared to other analogues (IIIa, IIIc, IIId and IIIe) against S.aureus, and E.coli and C.abicans.The antibacterial and antifungal activities of the compounds were compared with the standard drugs like Ciprofloxacin and Miconazole respectively.