Asian Journal of Research In Chemistry
  • Year: 2012
  • Volume: 5
  • Issue: 7

Synthesis of 1-Heterocyclicaminomethyl-3-(4′-arylamino-3′-nitrozoylhydrazono)-2-indolinones: Search of some new antifilarial compounds – IV

  • Author:
  • B.N. Singh1,, Sachendra Kumar Mishra1, Meera Singh1, K.K. Ojha2, Vivek Gupta3
  • Total Page Count: 5
  • Page Number: 913 to 917

1Chemistry Department Sri Baldeo P.G. College Baragaon, Varanasi, 221204 (U.P.)

2B.R.D. College, Deoriya

3S.V. College of Engineering and Technology, Muzaffar Nagar (UP)

*Corresponding Author E-mail: bnsinghsbpgc@rediffmail.com

Online published on 7 February, 2013.

Abstract

Twelve 1-Heterocyclicaminomethyl-3-(4′-arylamino-3′-nitrozoylhydrazono)-2-indolinones (Via-VIl) were synthesized starting from 4-chloro-3-nitrobenzoic acid. All these compounds were subjected for antifilarial testing on cotton rats infected with L. Carinii. Compound VIj was found to be most active showing 79, 55.7 and 88.8% reduction in mf count on the day 8, 21 and 42 respectively.

Keywords

DEC, L. carinii, antifilarial activity