Asian Journal of Research In Chemistry

  • Year: 2012
  • Volume: 5
  • Issue: 9

Microwave Assisted Greener Synthesis of Indazoles via one pot two step Cyclization of Hydrazone Hydrate

  • Author:
  • Anuruddha Chabukswar1,, Bhanudas Kuchekar1, Pradeep Lokhande2, Mangesh Tryambake1, Jayprakash Sangshetti3, Bharat Pagare1, Pandurang kadam1
  • Total Page Count: 6
  • DOI:
  • Page Number: 1195 to 1200

1Department of Pharmaceutical Chemistry, MAEER'S Maharashtra Institute of Pharmacy, Kothrud, Pune-411038, Maharashtra, India

2Center for Advanced Studies, Department of Chemistry, University of Pune, Pune -411007, Maharashtra, India

3Y. B. Chavan College of Pharmacy, Aurangabad, Maharashtra, India

Abstract

A highly efficient and eco-friendly one-pot microwave assisted method for synthesis of 1-H-indazole and 1-phenyl1H-indazoles is developed. Microwave heating of salicylaldehyde and hydrazine hydrates yielded the aryl hydrazones which further cyclized to afford indazoles. Microwave assisted method results in good to excellent yields of indazoles than the conventional method.

Keywords

Hydrazine hydrate, hydrazone, Indazole, Microwave, Salicylaldehyde