Synthesis and Antimicrobial activity of 2-hydroxy-5-methyl-3-nitro acetophenone thiazole Complexes of Co(II), Ni(II), Cu(II) and Zn(II).

A newly synthesized 2-hydroxy-5-methyl-3-nitro acetophenone thiazole Schiff base ligand was derived from the condensation of 2-hydroxy-5-methyl-3-nitro acetophenone and thiazole. The Schiff bases behaved as charge bidentade ligand. The ligand was characterized by elemental analysis and spectral methods. The coordinating ability of the ligand is investigated by preparing its metal complexes with Co(II), Ni(II), Cu(II) and Zn(II) have been prepared and characterized by elemental analysis, conductance measurements, molecular weight determinations and spectral studies. The Schiff base and their metal complexes have been evaluated for their antibacterial activities The synthesized products are coloured solids, soluble in DMF, DMSO and THF.