Absorption Ratio Method for Simultaneous Estimation of Dicyclomine Hydrochloride and Dexketoprofen Trometamol

Developed Absorption Ratio Method is a simple, rapid, accurate and robust spectroscopic method for simultaneous estimation of Dicyclomine Hydrochloride and Dexketoprofen Trometamol in bulk and Synthetic mixture. The wavelengths selected for Absorption ratio method were 260.0 nm (λ_max of DEX) and 311.5 nm(iso-absorptive point). Linearity range was found to be 14–24 μg/mL for Dicyclomine and 35–60 μg/mL for Dexketoprofen with r² value more than 0.999. Various validation parameters like linearity-range, precision, accuracy, robustness, LOD and LOQ were checked. % RSD was found to be less than 2 for repeatability and intermediate precision. % Recovery was found 99.025 ± 0.38 and 101.233 ± 0.18 for Dicyclomine Hydrochloride and Dexketoprofen Trometamol respectively. The developed method can be successfully applied for simultaneous estimation of Dicyclomine Hydrochloride and Dexketoprofen Trometamol.