Darivatization and Pharmacological Evaluation of New 4 Substituted 5 -Phenyl-3-Mercapto-1,2,4–Triazoles

An efficient method for synthesis of 4 substituted 5 -phenyl -3-mercapto -1, 2, 4 –triazole, by the mode of ring cleavage of oxadiazoles, nucleophiles are readily attack 5-phenyl 1,3,4-oxadiazole-2 – thiols and they are cleaved by acids and basis, in a reaction, which is the reverse of the ring closure, many nucleophilic ring cleavage reaction are followed by recyclization to give different heterocyclics, we were sysnthsized 5 different compounds and characterized its physical data, spectral analysis by IR and these compounds screened for possible CNS activity.