Asian Journal of Research In Chemistry
  • Year: 2013
  • Volume: 6
  • Issue: 8

Development and Validation of Simultaneous Equation UV-Spectrophotometric Method for the Estimation of Telmisartan and Amlodipine besylate in Combined Dosage Form

  • Author:
  • Shishir Maheshwari1,, Preeti Tiwari2, Atul srivastav1
  • Total Page Count: 4
  • Page Number: 765 to 768

1Department of Pharmaceutical Chemistry, IIMT College of Medical Sciences, Meerut-250001

2HOD, Department of Pharmaceutical Chemistry, IIMT College of Medical Sciences, Meerut

*Corresponding Author E-mail: shishirpharma@gmail.com

Online published on 21 September, 2013.

Abstract

A simple, sensitive, precise and specific UV spectrophotometric method for simultaneous estimation of Telmisartan and Amlodipine besylate in combine dosage form has been developed. The wavelengths 238 nm and 295 nm were selected for estimation of Amlodipine besylate and Telmisartan respectively, where Methanol was used as solvent. Linearity were observed in the concentration range of 2–25 μg/ml (r2=0.9994) and 2–30 μg/ml (r2=0.9999) for Telmisartan and Amlodipine besylate respectively. These methods were validated according to ICH guidelines.

Keywords

Telmisartan, Amlodipine besylate, Simultaneous equation method