Department of Chemistry, College of Education for Girls, University of Kufa, Najaf, Iraq
*Corresponding Author E-mail: hanan.alshebly@uokufa.edu.iq
Online published on 31 October, 2013.
In this present study, p-amino acetophenone condensed with p-nitro benzaldehyde in ethanolic solution of sodium hydroxide to yield corresponding chalcone, which reacts with various aromatic aldehydes in glacial acetic acid to yield corresponding Schiff bases. These chalcones were further reacted with urea, thiourea, guanedin in the presence of base in ethanol, which led to the formation of pyrimidine derivatives. Thin layer chromatography was used to follow the reactions. All the compounds have been characterized by FT-IR Spectroscopy, some of them characterized by (1H NMR)-spectra and elemental analysis (C.H.N).
Synthesis of chalcone, Pyrimidine
