Synthesis and Anti-Inflammatory Activity of Some 4,5 Diphenyl Pyrrole Derivatives

An efficient synthesis of different novel 4,5–diphenyl pyrrole derivatives by the paal-knorr condensation has been accomplished using substituted aniline and 1,4 – diketone. The synthesized compounds were confirmed through spectral characterization using IR, 1H NMR. The pyrrole derivatives examined for their in vitro antimicrobial activity and in vivo anti-inflammatory. Result indicated that these compounds showed promising anti microbial and antiinflammatory activity in comparison to amoxicillin and ibuprofen (the standard antimicrobial and anti–inflammatory drugs). Tolmetin (Rumatol) and Ketorolac (Ketolac), nonsteroidal anti-inflammatory drugs (NSAIDs) containing pyrrole ring, are nonselective inhibitors of cyclooxygenase 1 and 2 enzymes that led to decrease prostaglandin synthesis.