1Sree Dattha Institute of Pharmacy, Sheriguda, Ibrahimpatnam, Hyderabad, India
2Roland Institute of Pharmaceutical Sciences, Khodashing, Berhampur, India
3Department of Zoology, Berhampur University, Berhampur, India
*Corresponding Author E-mail: pratappatra83@gmail.com
Online published on 27 March, 2014.
Various Quinazolinone clubbed Pyrazole derivative compounds (7a1,7a2,7b1,7b2) were synthesized as per standard chemical procedure and characterized by physical and spectral analysis. Quinazolinone nucleus was synthesized using anthranilic acid as starting material and then it clubbed with Pyrazole moiety. The antimicrobial activity of all the synthesized compounds was evaluated separately for their possible antifungal activity against common pathogenic microorganisms Candida albicans and Aspergillus niger by cup plate method and anthelmintic activity by using common Indian earthworm Pheritima posthuma. Ketokonazole was used as a standard antifungal drug and albendazole, piperazine citrate as standard antihealmintic drug in this study.
Pyrazole, Quinazolinone, Antifungal, Anthelmintic, Ketokonazole
