Synthesis, Characterization and Antimicrobial Activity of Amino acids and Heterocyclic amines Coordinating Cu(II) Complexes

The mixed ligand complexes of Cu(II) with amino acids and heterocyclic amines have been synthesized and characterized on the basis of metal estimation, conductivity and magnetic measurements, infrared spectra and electronic spectra studies. The complexes were of [M(DA)₂L₂] or [M(DA)L₂] where M = Cu(II) and DA= deprotonated amino acids as a primary ligand, such as glycine and cysteine; L= heterocyclic amines as a secondary ligand, such as quinoline, isoquinoline pyridine, 1, 10-phenanthroline, 8-hydroxyquinoline, 2-picoline, 4-picoline. Antibacterial activity of the complexes has been examined against six (gram positive and gram negative) pathogenic bacteria by disc diffusion method and compared with that of standard antibiotic (Kanamycin). The complexes have been found to have moderate to strong antibacterial activity against the tested bacteria. All the compounds showed positive results that they are biologically active.