Synthesis and Evaluation of Some New Benzimidazole Derivatives for their Anti-Microbial and Anti-Inflammatory Activities

The synthesis, structure and biological activity of Benzimidazole derivatives have long been the focus of research interests in the field of Medicinal Chemistry. A number of Benzimidazole derivatives have been reported to possess interesting biological activities such as antimicrobial activity, 5-HT4 Receptor Antagonists activity, anticancer activity.

All synthesized compound were characterized by IR, H¹-NMR and elemental Analysis. All the compounds were evaluated for Antibacterial activity at the concentration of 200 μcg/mL by using cup-plate agar diffusion method. The activity was carried out on different micro-organisms (E.coli, S. aureus, A. niger, C. albicans) measured in terms of zone of inhibition and compared the standard drug Levofloxacin and Amphotericin B for antimicrobial activity. All the newly synthesized derivatives were screened for Anti-inflammatory activity by an in-vitro method of Inhibition of protein denaturation using Ibuprofen as a standard. These compounds with the suitable molecular modification may prove as a drug of choice in the treatment of microbial infectious disease in future.