Synthesis and Antibacterial, Anti-inflammatory and Anti-oxidant activity of 4-Acetamido-N-(3-Substituted-4-Fluorophenyl) Benzamides

The extensive use of antimicrobial drugs resulted in drug resistance that threatens to reverse the miracles of the last half century. To counteract the resistance produced by microbes there is a need to invent new drugs, which are more safe and effective. Now a day's vast number of compounds with fluorobenzene moiety feature in diverse areas like antibacterial, antifungal, anti-inflammatory, psychoactive agents etc. Benzamides are an important group of compounds with a wide range of biological activities. By considering the above facts, in this project, the syntheses of various 4-Acetamido-N-(3-substituted-4-fluorophenyl) benzamide derivatives has been carried out for better anti-bacterial, anti-inflammatory and anti-oxidant activity. A series of targeted compounds were synthesized by the two schemes and all derivatives were identified and characterized. Compounds 8a, 8b and 10a have shown moderate activity against Staphylococcus aureus. Compounds 8a, 8c and 10a were found to possess good anti-inflammatory activity when compared to Diclofenec sodium. The study regarding anti oxidant activity shown that synthesised compounds are not anti-oxidants.