Asian Journal of Research In Chemistry
  • Year: 2014
  • Volume: 7
  • Issue: 3

Synthesis and Anticancer Activity of Novel Substituted 1,3,4-oxadiazolo-[3,2-a]-1,3,5-triazine and 1,3,4-thiadiazolo-[3,2-a]-1,3,5-triazine Derivatives

  • Author:
  • Deepak Kumar Basedia, Birendra Shrivastava1, B. K. Dubey2, Pankaj Sharma1
  • Total Page Count: 6
  • Page Number: 310 to 315

1School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India

2T.I.T. College of Pharmacy, Anand Nagar, BHEL, Bhopal, Madhya Pradesh, India

*Corresponding Author E-mail: deepakbasediatit@gmail.com

Online published on 19 June, 2014.

Abstract

A new class of heterocyclic compounds 1,3,4-oxadiazolo-[3,2-a]-1,3,5-triazine and 1,3,4-thiadiazolo-[3,2-a]-1,3,5-triazine derivatives have been synthesized. The structures of these compounds have been confirmed by spectral analysis (IR, NMR & Mass). The title compounds were then evaluated for their In vitro cytotoxic activity by MTT assay method and NR assay method using breast cancer cell lines (MCF-7 and MDA MB 231). Newly synthesized compounds have shown promising anticancer activity.

Keywords

1,3,5-Triazine, In-vitro cytotoxic, Breast cancer, Cell lines MCF-7, MDA MB 231