Recent Advances and Potential Antimicrobial Activities of Thiazolidinone Derivatives: A Review

Heterocyclic systems are one of the most important classes of organic compounds present in nature or synthesized in laboratory. These compounds possess an array of biological activities and are employed in the treatment of commonly occurring diseases. This has been the backbone for chemists to impart interest for synthesizing some novel derivatives of possible high biological activity. In the last few decades, the chemistry of five_membered heterocyclic rings has received considerable attention owing to their synthetic and effective biological importance. One such class of compound is thiazolidinone. The synthesis of novel thiazolidinone derivatives and investigation of their chemical and biological behavior have gained more importance in recent decades for medicinal point of view. The thiazolidinone chemistry has been developed extensively and is still developing. Presently there are a number of drugs used clinically which comprise thiazolidinone moiety in association with various heterocyclic rings. The present review deals with therapeutic potential of thiazolidinone derivatives and special emphasis is given on recently reported thiazolidinone analogues possessing antimicrobial activity.