Niosomes used as Targeting Drug Delivery System: A Overview

Drug targeting System, the carriers are the ability to show a therapeutic action on the specific site; which is prior to be desired having little or no interaction with non-target tissue. Niosomes are non-ionic surfactant, these are the one of the best carrier for novel drug delivery system. They can improve the therapeutic performance of the drug molecule by delayed clearance from the circulation, protecting the drug from biological environment and restricting effects to the target cells. Niosomes can be found in various different sizes, they can be SUV (small unilamelar vesicles), MUV (multi-lamellar vesicle) or LUV (large uni-lamellar vesicles). The method of preparation of niosomes are quite similar to liposomes. In hydration method two phases are formed aqueous phase and lipid phase which may either a pure surfactant or mixture of surfactant with cholesterol. They may be less toxic are showing good release profile. Cholesterol which is a steroid derivative and used in formulation of niosomes but may not show any role in the formation of bi-layer. Here cholesterol affect properties of niosomes like membrane permeability, Rigidity, encapsulation efficiency, ease of rehydration of freeze dried Niosomes and their toxicity. It prevent the vesicle aggregation Niosomes appears to be a well preferred drug delivery system over liposomes as noisome being stable and economic.