Asian Journal of Research In Chemistry
  • Year: 2014
  • Volume: 7
  • Issue: 8

A Facile Synthesis of 2, 3-Dimethyl Benzocyclohepten-5-one

  • Author:
  • Prasad Gundepaka1,2,3, Shravankumar Kankala4, Mukkanti Kagga2, Chandra Sekhar Vasam1,
  • Total Page Count: 4
  • Page Number: 698 to 701

1Department of Chemistry, Satavahana University, Karimnagar, India-505 001

2Centre for Pharmaceutical Science, Institute of Science and Technology, JNTU, Hyderbad, India

3Inogent Laboratories Private Limited, (A GVK BIO Company), Nacharam, Hyderabad, India

4Department of Chemistry, Kakatiya University, Warangal, India-506 009

*Corresponding Author E-mail: vasamcs@yahoo.co.in

Online published on 22 October, 2014.

Abstract

The use of lithium chloride in boiling dimethylformamide has been shown to give high yields of 2,3-dimethyl benzocyclohepten-5-one from 2,3-dimethyl-6,6-dibromo-6,7,8,9-tetrahydrobenzocyclohepten-5-one. Similar elimination occurs from 2,3-dimethyl-6,9-dibromo-6,7,8,9-tetrahydrobenzo-cyclohepten-5-one to give 2,3-dimethyl benzocyclohepten-5-one.

Keywords

Lithium chloride, dimethylformamide, NBS, cyclohepten-5-one