Synthesis, Characterization of some Novel 6h-Indolo (2, 3-b) Quinoxaline Fused Azetidinones as Potential Bioactive Molecules

Synthetic analogs of indoles and azetidinones are reported to possess various pharmacological activities such as anti-inflammatory, antidepressant, neuroleptic, cytotoxic, antitubercular, antihypercholesterolemic, antioxidant activities along with wide range of antimicrobial activity. Isatin (indole-2, 3-dione) on treatment with o-phenelynediamine in presence of ethanol and glacial acetic acid gave 6H-indolo(2, 3 b)quinoxaline [M1] which on treatment with ethylchloroacetate gave Ethyl [6H-indolo(2, 3 b)quinoxaline)-1-acetate [M2] which on amination with hydrazine hydrate afforded 6H-indolo(2, 3 b)quinoxaline-1-acetic acid hydrazide[M3]. New series of N-(3-chloro-2 oxo-4 aryl azetidine-1-yl)-2-[6H-indolo (2, 3 b) quinoxaline-6-yl] acetamides[M4] were synthesized by condensation of 6H-indolo (2, 3b) quinoxaline-1-acetic acid with different aromatic aldehydes to produce a series of schiff s bases. β-lactam moiety was incorporated on Schiff s base through cycloaddition reaction using chloroacetyl chloride in presence of triethyl amine. The synthesized compounds were charecterised by IR, ¹H NMR and Massspectral studies. All the newly synthesized compounds have been evaluated for their antimicrobial activity against gram-positive and gram-negative bacteria and fungi The synthesized compounds were active against gram positive, gram negative bacterial and fungal species. Para nitro substituted derivatives are good antimicrobial agents among all the derivatives.