Asian Journal of Research in Chemistry

2-Amino-3-cyano-4, 5-disubstituted thiophene JSR-2 was synthesized using 2-amino-3-cyano-4,5-disubstituted thiophene. First step is preparation of 2-amino-3-cyano-4,5-disubstituted thiophene (JSR-c) which was carried out by condensation of diethylamine, cyclohexanone, Malononitrile and sulphur this compound was refluxed with formamide and acetic anhydride to give 4-Amino-5,6-disubstituted thieno [2,3-d] pyrimidines. Then the parent compound was treated with different substituted aryl aldehydes by microwave irradiation method to yield new series of Schiff bases (JSR 7a-7k). The compounds were characterized IR, ¹H NMR and mass spectral data and screened for anti-inflammatory activity.