Asian Journal of Research in Chemistry

Schiff bases were synthesized by microwave irradiation method by using different substituted aldehydes with substituted thienopyrimidines. 4-Amino-5,6-dimethyl thieno [2,3-d] pyrimidine JSR-8 was synthesized using 2-amino-3-cyano-4,5-disubstituted thiophene. First step was preparation of 2-amino-3-cyano-4,5-dimethyl thiophene (JSR-D) which was carried out by condensation of diethylamine, ethylmethylketone, Malononitrile and sulphur then the solid obtained was refluxed with formamide and acetic anhydride to give 4-Amino-5,6-dimethyl thieno [2,3-d] pyrimidine. Finally the parent compound was treated with different substituted aryl aldehydes by microwave irradiation method to yield new series of Schiff bases (JSR 8a-8k). The compounds were characterized IR, ¹H NMR and mass spectral data and screened for anti-inflammatory activity.