Asian Journal of Research in Chemistry
  • Year: 2015
  • Volume: 8
  • Issue: 4

3D QSAR and Pharmacophore Modelling of some Pyrimidine Analogs as CDK4 Inhibitors

Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Near Chitranagari, Kolhapur, 416 013, Maharashtra, India

*Corresponding Author E-mail: caddresearch15@gmail.com

Online published on 25 June, 2015.

Abstract

Cancer has a highest rate of mortality in the current decade. Breast cancer most prevalently observed cancer in recent years. In cancer, occurrence of corrupt cell cycle regulation leads to loss of orderly cell division. Over expression of cyclin-dependent kinases projects to carcinomas, amongst them CDK4 enzyme plays an important role in prevention of cancer. Nowadays, CDK4 is a major challenge in drug discovery to develop new anticancer agents. The present work deals with the 3D-QSAR and pharmacophore modelling of a series of pyrimidine analogs as CDK4 inhibitors.

Keywords

Pyrimidine, Pharmacophore modelling, 3D QSAR, CDK4, Anticancer agents