Asian Journal of Research in Chemistry
  • Year: 2015
  • Volume: 8
  • Issue: 4

Deriving Atom Economy Approach by Employing Dynamic Resolution of (3-Methoxy Phenyl)-(3-N, N-Dimethyl Amino)-2-Methyl Propanone

  • Author:
  • G. Venkanna1,2, G. Madhusudhan1,, K. Mukkanti2, K. Chandra Babu1, P. Venkateswarlu1
  • Total Page Count: 6
  • Page Number: 267 to 272

1Department of Research and Development, Inogent Laboratories Private Limited (A GVK BIO Company), 28A, IDA, Nacharam, Hyderabad-500 076, India

2Centre for Chemical Sciences and Technology, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad-500 072, India

*Corresponding Author E-mail: madhusudhan.gutta@yahoo.com

Online published on 25 June, 2015.

Abstract

Racemic 3-Subsituted phenyl-3-(dimethylamino)-2-methylpropan-1-one resolved by means of a dynamic diastereomeric salt formation using di-Benzyl-L-tartaric acid with PTSA. The salts are formed in excellent yields and diastereomeric excesses.

Keywords

Tapentadol Hydrochloride, centrally acting analgesic, Dynamic resolution, Atom aconomy, asymmetric synthesis