Asian Journal of Research in Chemistry

  • Year: 2015
  • Volume: 8
  • Issue: 5

Synthesis and Screening of Mcrex-1

1Department of Pharmacy, AIKTC School of Pharmacy, New Panvel, Mumbai

2Department of Pharmaceutical Chemistry, NGSMIPS, Deralakatte, Mangalore

3Department of Pharmaceutical Chemistry, VIP Sciences, Rajahmundry, AP

Abstract

Methanol extract of dried leaves of Momordica charantia Linn (Cucurbitaceae), was investigated for antihyperglycemic activity in CTZ induced diabetics rat model, the results shows a significant reduction of blood glucose level to normal when compared with standard. The activity guided extract, subjected to isolation, which led to getting five bioactive constituents, among which one molecule selected for screening and synthesis.

Keywords

Momordica charantia Linn, diabetics, anti-hyperglycemic