1District Tuberculosis Centre, Kanpur, Uttar PradeshIndia-208001
2District Tuberculosis Centre, Kanpur Dehat, Uttar Pradesh, India-Pin Code-209111
3P.K.S.S. Mahavidyalaya, Kanpur Dehat, Uttar PradeshIndia-209111
4Naiminath Homoeopathic Medical College, Hospital and Research Centre, Nawalpur, Agra-283202, (U.P.), India
A number of aldehydes and ketones were condensed with 2, 4-dinitro phenyl hydrazine to give corresponding 2, 4-dinitrophenyl hydrazones (Ia-Ic). Again aldehydes and ketones were reacted with 2-phenylacetohydrazide to give hydrazide-hydrazones (IIa-IIc). Structure of synthesized compounds were confirmed by elemental analysis and spectral data. The synthesized compounds were evaluated for anticonvulsant activity in maximial electroshock seizure (MES) test using phenytoin as standard drug. In which compound IIa was found most potent among the series.
Hydrazones, Hydrazide hydrazones, anticonvulsant activity, MES
