1Department of Chemistry, Krishna University, Machilipatnam, Andhra Pradesh, India
2Department of Chemistry, SVKP & Dr. K.S Raju Arts & Science College, Penugonda, A.P, India
3Department of Animal Science, Chonbuk National University, Jeonju, South Korea
4Department of Chemistry, DLR PG College, G. Mamidada, Andhra Pradesh, India
*Corresponding Author E-mail: tentu6581@rediffmail.com
Online published on 9 March, 2017.
A simple and inexpensive method was developed with high performance liquid chromatography with PDA detection for determination of Terbinafine HCl and related impurities. The chromatographic separations were achieved on (150×4.6 mm), 5.0 μm make: YMC-Pack ODS-AM, 120A column employing Acetonitrile: methanol and Water pH 7.5, in the ratio of 20:10:10 v/v/v as mobile phase with gradient programmed at flow rate 1.0 mL/min was chosen. Three impurities were eluted within 35 minutes. The detector wavelength of 230 nm was employed.
Forced degradation, HPLC, Method validation, Terbinafine
