Synthesis, Characterization of 3-Chloro 4-(4-Substituted Phenyl-1-(4-Nitro Phenylazetidin-2-one by Microwave Method and Evaluation of Their Antibacterial Activity

Non classical, High-speed, environmentally benign synthesis with microwaves has attracted researchers for organic synthesis was a considerable amount of attention in recent years. An expeditious one pot microwave irradiation method for preparation of 2-azetidinones is developed. This method has been assessed as greener methodology. In our present study, A series of six novel 2-azetidinones were synthesized, compounds were identified by melting point and thin layer chromatography, functional groups of synthesized compounds were confirmed by IR spectroscopy, compounds were evaluated for their antimicrobial activities. The activities were due to cyclic carbonyl group in 2-azetidinones. Some of the compounds have shown comparative antimicrobial activities against all the microbial strains.